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Neuronal Inputs And Outputs Of Aging And Longevity

Neuronal Inputs And Outputs Of Aging And Longevity
Author: Joy Alcedo
Publisher: Frontiers
ISBN: 2889191605
Size: 76.38 MB
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An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environments. This is achieved through intercellular communication not only within a single tissue but also among different tissues and organ systems. Thus, alterations in tissue-to-tissue or organ-to-organ communications, which are under genetic regulation, can affect organismal homeostasis, and consequently impact the aging process. One of the organ systems that play a major role in maintaining homeostasis is the nervous system. Considering that the nervous system includes the sensory system, which perceives the complexity of an animal’s environment, it should be no surprise that there would be a sensory influence on homeostasis and aging. To promote homeostasis, any given sensory information is transmitted through short-range signals via neural circuits and/or through long-range endocrine signals to target tissues, which may in turn be neuronal or non-neuronal in nature. At the same time, since homeostasis involves a number of feedback mechanisms, non-neuronal tissues can also modulate sensory and other neuronal functions. Several genes that regulate signaling pathways known to affect homeostasis and aging have been shown to act in neurons, in tissues that are likely downstream targets of the nervous system, or through feedback regulation of neuronal activities. These genes can have different temporal requirements: some might function early, e.g., by affecting neural development, while others may only be required later in adulthood. Some well-known examples of genes involved in the neuronal regulation of homeostasis and longevity encode components of the evolutionarily conserved nutrient-sensing insulin/insulin-like signaling pathway, the stress-sensing internal repair system, and the mitochondrial electron transport chain. Indeed, the genetic perturbation of these pathways has been found to lead to numerous diseases, many of which are age-related and involve the nervous system, such as neurodegeneration and the metabolic syndrome. Despite much progress, however, many aspects of the neuronal inputs and outputs that affect aging and longevity are poorly understood to date. For example, the precise neuronal and non-neuronal circuitries and the details of the molecular mechanisms through which genes/signaling pathways maintain homeostasis and affect aging in response to the environment remain to be elucidated. Similarly, it is presently unclear whether genes that regulate the early development of the nervous system and its consequent circuitry influence homeostasis and longevity during adulthood. At the same time, although many genes affecting aging are conserved, both the nervous system and the aging process are highly variable within populations and among taxa. Accordingly, the role of natural genetic variation in shaping the neurobiology of aging is also presently unknown. The aim of this Research Topic is therefore to highlight the genetic, developmental, and physiological aspects of the signaling networks that mediate the neuronal inputs and outputs that are required to maintain organismal homeostasis. The elucidation of the effects of these neuronal activities on homeostasis may thus provide much-needed insight into mechanisms that affect aging and longevity.
Neuronal Inputs and Outputs of Aging and Longevity
Language: un
Pages:
Authors: Joy Alcedo, Thomas Flatt, Elena G. Pasyukova
Categories:
Type: BOOK - Published: 2013-08-23 - Publisher: Frontiers
An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environments. This is achieved through intercellular communication not only within a single tissue but also among different tissues and organ systems. Thus, alterations in tissue-to-tissue or organ-to-organ communications, which are under genetic regulation, can affect organismal homeostasis, and consequently impact the aging process. One of the organ systems that play a major role in maintaining homeostasis is the nervous system. Considering that the nervous system includes the sensory system, which perceives the complexity of an animal’s environment, it should be no surprise that there would be a sensory influence on homeostasis and aging. To promote homeostasis, any given sensory information is transmitted through short-range signals via neural circuits and/or through long-range endocrine signals to target tissues, which may in turn be neuronal or non-neuronal in nature. At the same time, since homeostasis involves a number of feedback mechanisms, non-neuronal tissues can also modulate sensory and other neuronal functions. Several genes that regulate signaling pathways known to affect homeostasis and aging have been shown to act in neurons, in tissues that are likely downstream targets of the nervous system,
Biology of Longevity and Aging
Language: en
Pages: 720
Authors: Robert Arking
Categories: Family & Relationships
Type: BOOK - Published: 2019 - Publisher: Oxford University Press, USA
Revised edition of: Biology of aging: observations and principles. 2006.
Handbook of Geriatric Communication Disorders
Language: en
Pages: 494
Authors: Danielle Newberry Ripich
Categories: Medical
Type: BOOK - Published: 1991 - Publisher: Pro Ed
Books about Handbook of Geriatric Communication Disorders
Mechanisms Underlying Age-related Cognitive Decline and Sensitivity to Brain-derived Neurotrophic Factor
Language: en
Pages: 338
Authors: David Arthur Merrill
Categories: Medical
Type: BOOK - Published: 2002 - Publisher:
Books about Mechanisms Underlying Age-related Cognitive Decline and Sensitivity to Brain-derived Neurotrophic Factor
Proceedings
Language: en
Pages:
Authors: International Conference on Neural Networks 1995, Perth, Western Australia
Categories: Medical
Type: BOOK - Published: 1995 - Publisher:
Books about Proceedings
Dissertation Abstracts International
Language: en
Pages:
Authors: International Conference on Neural Networks 1995, Perth, Western Australia
Categories: Dissertations, Academic
Type: BOOK - Published: 2008 - Publisher:
Books about Dissertation Abstracts International
Current Directions in Developmental Psychology
Language: en
Pages: 175
Authors: Jacqueline Lerner, Amy E. Alberts
Categories: Psychology
Type: BOOK - Published: 2007-06 - Publisher: Allyn & Bacon
CURRENT DIRECTIONS IN DEVELOPMENTAL PSYCHOLOGY, an Association for Psychological Science reader, edited by Jacqueline Lerner, Boston College, and Amy E. Alberts, Tufts University. This new and exciting reader includes over 20 articles that have been carefully selected for the undergraduate audience, and taken from the very accessible Current Directions in Psychological Science journal. These timely, cutting-edge articles allow instructors to bring their students real-world perspective-- from a reliable source--about today's most current and pressing issues in developmental psychology. For details or to find out how to get these readers for FREE when purchased with Allyn and Bacon Psychology texts, please contact your local Allyn and Bacon sales representative.
Health Promotion Strategies Through the Life Span
Language: en
Pages: 881
Authors: Ruth Beckmann Murray, Judith Proctor Zentner
Categories: Medical
Type: BOOK - Published: 2001 - Publisher:
For Nursing Courses in Growth and Development, Health Promotion or Basic Clinical Theory in the Fundamentals of Nursing.Using a practical, holistic approach to the health care of individuals and families, this text offers specific guidelines for holistic health assessment, with suggested nursing interventions and health promotion strategies at each developmental stage from birth to death. Unique in its comprehensive, consistent, and integrated format, it covers the physical, cognitive, emotional, sociocultural and spiritual aspects of development for each life stage individually in equal depth and breadth.
Science and Quality of Life
Language: en
Pages: 620
Authors: Syed Zahoor Qasim
Categories: Quality of life
Type: BOOK - Published: 1993 - Publisher:
In the Indian context; contributed articles.
Excerpta Medica
Language: en
Pages:
Authors: Syed Zahoor Qasim
Categories: Physiology
Type: BOOK - Published: 1991 - Publisher:
Monthly. References and abstracts to international journal literature in the field of physiology. Classified arrangement of entries. Subject, author index.